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This episode challenges common perceptions about exercise, delving deep into the benefits of vigorous exercise for not just physical health but also brain function, aging, and even cancer prevention. It tackles fundamental questions, like what genetic and metabolic adaptations occur with vigorous exercise and how it can contribute to combating heart's age-related changes. We also unpack how these rigorous exercises affect glucose transport, mitochondrial health, and brain health at an intricate level. Lastly, it introduces practical applications like the Norwegian 4x4 interval training protocol, the benefits of "exercise snacks," and how to incorporate vigorous-intensity exercise into everyday life.

Rachel Cruze & Dr. John Delony answer your questions and discuss:

"Should we buy long-term care insurance?"

"How do we deal with a setback in our budget?"

"Should we wait to move for a new job?"

"When do I stop investing?"

"I don't know where our money is going,"

"Can we pause investing to grow our business?"

"Does it make sense for us to combine finances?"

"How do we best leave real estate to our kids?"

"Grieving a cancer diagnosis,"

"Paying off debt while still in school,"

"We aren't getting the promised solar tax breaks,"

"Should I use a debt consolidation loan?

23andMe's Anne Wojcicki joins Jason for a deep dive on genome testing and healthcare. They cover the dramatic reduction in genome sequencing costs from billions to just $99, the role of blood testing and sequencing in shaping 23andMe's health approach, the curious case of the venomous Gila monster, and much more!

Andrew Huberman, PhD (@hubermanlab), is a neuroscientist and tenured professor in the Department of Neurobiology at Stanford University’s School of Medicine. He has made numerous important contributions to the fields of brain development, brain function, and neural plasticity. Work from the Huberman Laboratory at Stanford Medicine has been consistently published in top journals including Nature, Science, and Cell.

Andrew is the host of the podcast Huberman Lab, which is often ranked as one of the top five podcasts in the world by both Apple and Spotify. The show aims to help viewers and listeners improve their health with science and science-based tools. New episodes air every Monday on YouTube and all podcast platforms.

Please enjoy!

This episode was originally published in July, 2021. Show notes and resources from this episode: https://tim.blog/2021/07/06/andrew-huberman/

The practical wisdom of Poor Charlie's Almanack, this ode to curiosity, generosity, and virtue will similarly compound at successive generations of entrepreneurial readers extend his lessons to their own circumstances.

Education is the process whereby the ability to lead a good life is acquired.

Trust is one of the greatest economic forces on earth.

Charlie is content to trust his own judgment when it runs counter to the wisdom of the herd.

Aim for durability. Durability has always been a first rate virtue in Charlie’s eyes.

Charlie only focuses on great businesses and great businesses have moats.

You can flourish in a niche: People who specialize in the business world —and get very good because they specialize— frequently find good economics that they wouldn't get any other way.

Being so well known has advantages of scale. This is what you might call an informational advantage. It increases social proof.

Occasionally scaling down and intensifying gives you a big advantage. (You can find great profit margins this way)

Scale and fanaticism combined is very powerful. (Think Sam Walton)

I also believed then, as I do now after more than fifty years as a money manager, that the surest way to get rich is to play only those games or make those investments where I have an edge.

The best thing a human being can do is help another human being know more.

Optimism is a moral duty. — Edwin Land

You want to maximize the playing time of your top players.

The game of competitive life often requires maximizing the experience of the people who have the most aptitude and the most determination as learning machines.

The most important rule in management is get the incentives right.

Never, ever think about something else when you should be thinking about the power of incentives.

J.D. Salinger was a complicated and problematic human who stopped publishing soon after creating one of the great works of literature. Listen in today to learn the good, bad and ugly sides of the man who got famous, then dropped out.

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